Gene expression in hypothalamus, liver, and adipose tissues and food intake response to melanocortin-4 receptor agonist in pigs expressing melanocortin-4 receptor mutations
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چکیده
منابع مشابه
Gene expression in hypothalamus, liver, and adipose tissues and food intake response to melanocortin-4 receptor agonist in pigs expressing melanocortin-4 receptor mutations.
Transcriptional profiling was used to identify genes and pathways that responded to intracerebroventricular injection of melanocortin-4 receptor (MC4R) agonist [Nle(4), d-Phe(7)]-α-melanocyte stimulating hormone (NDP-MSH) in pigs homozygous for the missense mutation in the MC4R, D298 allele (n = 12), N298 allele (n = 12), or heterozygous (n = 12). Food intake (FI) was measured at 12 and 24 h af...
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متن کاملexpression of melanocortin 4 receptor mrna in male rat hypothalamus during chronic stress
the effects of chronic stress and glucocorticoids receptor antagonist (ru486) on expression of melanocortin 4 receptor (mc4r) mrna in arcuate nucleus (arc) of male rats were evaluated. in this study, adult male sprague dawley rats were placed into four groups (n=6/group) stress, ru486, stress/ru486, and control groups. in stress group, the rats were restrained, 1 h/day, for 12 days. in ru486 gr...
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ژورنال
عنوان ژورنال: Physiological Genomics
سال: 2010
ISSN: 1094-8341,1531-2267
DOI: 10.1152/physiolgenomics.00006.2010